Complex lower limb wounds represent a great challenge for both the vascular surgeons and vascular nurses as it often requires advanced wound management strategies following the vascular surgical intervention. The advanced wound management methods commonly used to facilitate wound healing including topical oxygen therapy (TOT), larvae therapy, negative pressure wound therapy (NPWT). This presentation will discuss two of the advanced wound management methods naming the TOT and larvae therapy used at the tertiary referral centre for management of patients with lower limb / foot wound, and patient outcome following the selected wound management therapy. Selection criteria for this review: Patients who had TOT management: lower limb or foot wound with TOT treatment duration of three weeks or more, N=3. Patients who received larvae therapy: Ischaemic foot wounds following vascular surgical intervention, N=3.