Limb salvage represents a critical goal in the management of complex vascular and musculoskeletal pathologies. The integration of a dedicated vascular center within a multidisciplinary framework significantly improves the success of limb preservation by enabling timely revascularization, advanced endovascular and open surgical techniques, and coordinated perioperative care. Collaboration between vascular surgeons, orthopedic specialists, plastic and reconstructive teams, and rehabilitation experts ensures a comprehensive strategy that maximizes functional outcomes and reduces amputation rates. The establishment of specialized vascular centers is therefore pivotal to advancing limb salvage and enhancing patient quality of life