Purpose: During the COVID-19 pandemic, the care of older patients admitted to hospital changed due to policies restricting visitors. The aim of this study was to explore nurses’ experiences of caring for patients with delirium in an Australian acute care setting, which also highlighted the impact of infection prevention and control measures implemented in response to the pandemic. Methodology: This interpretive, qualitative study recruited nurses from two acute aged care wards in a Sydney metropolitan tertiary hospital for semi-structured interviews to explore their experiences of caring for patients with delirium. Eleven interviews were recorded and transcribed verbatim. Data was analysed qualitatively using human factors principles as an interpretative lens. Findings: Experiences related to COVID-19 were extracted from the data. Participants experienced difficulties delivering patient-centred care due to the inability of family members to be present, resulting from public health orders and the implementation of visitor policies. Enforcing isolation and excluding the family resulted in care failing to meet nurses' expectations, with additional challenges in care provision and communication. Even with the use of technologies such as Zoom, which enables families to ‘see’ and interact with patients online, this didn’t have the same outcome as having family members physically present in the ward to assist with the care of patients with delirium. Conclusion: Nurses described an overwhelming sense of responsibility and moral injuries. The advice to place patients with delirium in isolation was inconsistent with the Australian Commission on Safety and Quality in Health delirium clinical care standard. Understanding the complexity and barriers to managing delirium during a pandemic, where there was rapid and, at times, conflicting information. Our findings will contribute to informing the implementation of controls in the event of future pandemics, including workforce preparation and support.