Outcomes of Calciphylaxis in a tertiary centre – A nursing perspective Heather Schulz,Prakash Balakrishnan ,Paula McKinnel,Lupe Taumoepeau, Elizabeth Suthers , Parth Sheth , Richard Evans ,JK Wickremesekera Purpose Calciphylaxis is a life-threatening disease due to progressive subcutaneous and dermal small vessel calcification resulting in tissue ischaemia ,thrombosis & necrosis mainly in end-stage renal disease patients. Difficulty in distinguishing it early from peripheral vascular disease led to this study. The focus is on clinical characteristics, diagnosis, early identification and the impact of nursing management on improving patient outcomes. We present a series of successful cases managed in our unit. Methodology A local database search conducted in a tertiary hospital screening for all calciphylaxis cases in the last 10 years. Incidence, demographic patterns, mortality and wound complications were documented. The time to diagnosis and referral pathways were analysed. Results Approximately 24 patients were identified , ranging from 39 to 81 years and 50% were Maori . Majority were end-stage renal failure patients on dialysis at time of onset. Nearly half of the patients had concurrent peripheral arterial disease requiring revascularisation. Around 25% of patients had major limb amputation. Only 12.5 % of patients were on warfarin and there was increasing use of sodium thiosulfate in a third of patients. A case series of 3 patients with calciphylaxis with positive outcomes were presented. Conclusion This study has several limitations, predominantly from the small cohort of patients due to poor electronic coding of disease in hospital electronic databases, the findings were descriptive rather than definitive. Success in managing calciphylaxis within the scope of nursing practice is influenced by increased nursing vigilance with early prompt diagnosis and a robust wound management plan. The hope is to improve local practices through collaboration and increased awareness.